The Pajama (Pardee, Jacob, Monod) experiment provided a breakthrough in our understanding of the molecular mechanisms by which gene expression is regulated. Today, twenty‐five years later it provides a paradigm for thinking about problems of gene expression, such as growth regulation and differentiation. From this experiment emerged entities such as repressors, regulatory genes, the operon as a group of jointly controlled genes, and messenger RNA.

One observes regulation at every biological level. Organisms, cells, and biochemical processes operate efficiently, normally wasting neither material nor energy, and adjusting their functions to external influences. Nature evidently has evolved mechanisms specifically dedicated to regulation at many levels. What is the molecular basis of this control?In the 1950s these molecular control mechanisms began to be explored seriously. The discoveries of feedback inhibition of enzyme activity were important because they gave an initial example of how regulation is achieved at the (...) molecular level. We showed that certain enzymes are composed of two parts, one for catalysis and another distinct part present only to regulate this catalysis. Catalytic activity can be either stimulated or inhibited when a small molecule in the environment combines with the enzyme's regulatory site. In particular, a final product of a metabolic pathway generates a feedback loop which automatically limits its own excessive production, by combining with the regulatory site of an early enzyme in that pathway. Later studies showed that catalytic and regulatory structures of some enzymes could be separated physically.The discovery of regulatory sites and their interaction with molecules unrelated to their substrates was the basis for the generalized allosteric concept. This concept extends the regulatory site idea to a wide variety of processes such as control of gene expression, hormone action, and cellular growth. (shrink)

It is important to take a developmental approach to the problem of analogy. One limitation of this approach, however, is that it does not deal with the complexity of making analogical inferences. There are a few key principles of analogical inference that are not well captured by the analogical relational priming (ARP) model.

The target article suggests that many practices of experimental economists are preferable to those used by psychologists studying judgment and decision making. The advantages of the psychological approach become clear when the focus of research shifts from choice output to choice processes. I illustrate this point with an example from research on similarity comparisons.

The computational paradigm, which has dominated psychology and artificial intelligence since the cognitive revolution, has been a source of intense debate. Recently, several cognitive scientists have argued against this paradigm, not by objecting to computation, but rather by objecting to the notion of representation. Our analysis of these objections reveals that it is not the notion of representation per se that is causing the problem, but rather specific properties of representations as they are used in various psychological theories. Our analysis (...) suggests that all theorists accept the idea that cognitive processing involves internal information-carrying states that mediate cognitive processing. These mediating states are a superordinate category of representations. We discuss five properties that can be added to mediating states and examine their importance in various cognitive models. Finally, three methodological lessons are drawn from our analysis and discussion. (shrink)

Representation is a central part of models in cognitive science, but recently this idea has come under attack. Researchers advocating perceptual symbol systems, situated action, embodied cognition, and dynamical systems have argued against central assumptions of the classical representational approach to mind. We review the core assumptions of the dominant view of representation and the four suggested alternatives. We argue that representation should remain a core part of cognitive science, but that the insights from these alternative approaches must be incorporated (...) into models of cognitive processing. (shrink)

In order to develop sophisticated models of the core domains of knowledge that support complex cognitive processing in infants and children, developmental psychologists have mapped out the content of these knowledge domains. This research strategy may provide a blueprint for advancing research on adult cognitive processing. I illustrate this suggestion with examples from analogical reasoning and decision making.

Machery argues that concepts are too heterogeneous to be a natural kind. I argue that the book does not go far enough. Theories of concepts assume that the task of categorizing warrants a unique set of cognitive constructs. Instead, cognitive science must look across tasks to find a fundamental set of cognitive mechanisms.

The European Legacy, Volume 17, Issue 4, Page 561-562, July 2012.

Each contributor to this book has used personal experience as the basis from which to frame his individual sociological perspectives. Because they have personalized their work, their accounts are real, and recognizable as having come from 'real' persons, about 'real' experiences. There are no objectively-distanced disembodied third person entities in these accounts. These writers are actual people whose stories will make you laugh, cry, think, and want to know more.

From 1945 to date Holocaust research has concentrated on complex matters such as militant Jewish resistance, convoluted Nazi strategies, ambivalent bystander behavior, controversial ghetto leadersh...

In the years immediately following WWII, between 1946 and 1948, there were four well-known salutatory responses to liberation by ex-captives. First, joyous Jewish survivors in Displaced Person (DP)...

Twenty-four capitals of Nazi-occupied countries suffered grievously under the jackboot heel of the Third Reich. In one capital, however, the situation was truly bizarre, and it takes an artful work...

It seems to have been taken for granted that we all know what a human action is. However in attempting to draw from what philosophers have said about actions the necessary clues as to their distinguishing features, one finds little to discourage the idea that there is no way of distinguishing one category of occurrences, human actions, from the complex of different sorts of things which happen. From this I am tempted to conclude that there is no category of human (...) action. But before drawing such a conclusion an ancient but terrible question must be faced: What sorts of things happen in the world ? This ancient question is faced but not answered. It is brought up because the failure to find a satisfactory answer to the question, Is human action a category? is a failure even to find a satisfactory assumption about what kind of reference the term ?human action? is supposed to have. (shrink)

The proposed model is put forward as a template for the dynamical systems approach to embodied cognition. In order to extend this view to cognitive processing in general, however, two limitations must be overcome. First, it must be demonstrated that sensorimotor coordination of the type evident in the A-not-B error is typical of other aspects of cognition. Second, the explanatory utility of dynamical systems models must be clarified.

The perceptual symbol system view assumes that perceptual representations have a role-argument structure. A role-argument structure is often incorporated into amodal symbol systems in order to explain conceptual functions like abstraction and rule use. The power of perceptual symbol systems to support conceptual functions is likewise rooted in its use of structure. On Barsalou's account, this capacity to use structure (in the form of frames) must be innate.

Tests of economic theory often focus on choice outcomes and find significant individual differences in these outcomes. This variability may mask universal psychological processes that lead to different choices because of differences across cultures in the information people have available when making decisions. On this view, decision making research within and across cultures must focus on the processes underlying choice.

Pothos suggests dispensing with the distinction between rules and similarity, without defining what is meant by either term. We agree that there are problems with the distinction between rules and similarity, but believe these will be solved only by exploring the representations and processes underlying cases purported to involve rules and similarity.

This essay argues that the affective component inherent in the enthymeme is the essence of aristotle's concept of the enthymeme as practical reasoning. 'affective component' refers to emotions and feelings. The three proofs of the thesis are the etymology of 'enthymeme', Aristotle's works on human action and practical wisdom, And aristotle's rhetoric. These sources show the inherent relation between enthymemes and phronesis, Or practical reasoning, Not nous, Or abstract intellect.